Messages from forgotten friends: classic cell adhesion molecules inhibit regeneration too.
نویسندگان
چکیده
A necessary step toward complete functional recovery after spinal cord injury is the regeneration of axons. Axon regrowth after injury is prevented by a myriad of intrinsic and extrinsic factors. In this issue of The EMBO Journal, Huang et al (2016) demonstrate that the cell adhesion molecule NB-3 (CNTN6) functions as a major brake on axon regrowth when it is activated by NB-3 from scar-forming cells at the injury site. Disruption of this NB-3 trans-cellular signaling led to impressive axon regrowth after spinal cord transection.
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ورودعنوان ژورنال:
- The EMBO journal
دوره 35 16 شماره
صفحات -
تاریخ انتشار 2016